IF I understood correctly, you want to matrix match your standards and QCs with your ammonium acetate samples, but your ammonium acetate samples very in concentration. You need to dilute the samples to have enough sample volume.
This sounds like maybe you have an HPLC analysis with an ammonium acetate gradient from which you are collecting fractions. If I am right, is there any chance you can still separate your unnamed analytes with an isocratic mobile phase? That would simplify matrix matching your standards.
If not, one solution would be to dilute the samples into a much higher concentration of ammonium acetate, maybe somewhere between 10 mM and 100 mM, so that the 1 mM difference among your samples would be negligible.
On the other hand, maybe I am wrong about my guess as to what you are doing. More info would have "Helped us help you." But then maybe you are doing something new and exotic that you don't want someone to scoop you on. I understand.
R. Steven Pappas, Ph.D.
Team Lead, Tobacco Inorganics Group
Centers for Disease Control & Prevention
4770 Buford Highway, NE
M.S. F44, Building 110
Atlanta, GA 30341-3717, USA
From: PLASMACHEM-L: Analytical Chem.(ICP's, DCP's, MIP's). <[log in to unmask]> On Behalf Of Kristin Gagne
Sent: Thursday, May 10, 2018 10:19 AM
To: [log in to unmask]
Subject: Ammonium Acetate Matrix Match
Hi List Members,
I am running an Aglient ICPMS 7500 and I understand I need to matrix match for my ammonium acetate samples (learned that the hard way). However, I am running into the issue that my samples vary in ammonium acetate concentrations. I needed to dilute up to have enough sample and so my ammonium acetate concentrations are around 2.14mM, 2.5mM, and 3.13mM. Any assistance would be greatly appreciated.
University of Alaska Fairbanks