Again, no intention of showing favoritism to one vendor over another, only responding to the question, we use single quad mode in combination with two different cell gas mass shift modes for some of our Agilent triple quad methods:
Pappas RS, Gray N, Gonzalez-Jimenez N, Fresquez M, Watson CH. Triple Quad ICP-MS measurement of toxic metals in mainstream cigarette smoke from Spectrum research cigarettes. J. Anal. Toxicol. 2016;40:43-48.
Pappas RS, Martone N, Gonzalez-Jimenez N, Fresquez MR, Watson CH. Determination of toxic metals in little cigar tobacco with 'Triple Quad' ICP-MS. J. Anal. Toxicol. 2015;39:347-352.
Due to the small cell volume, Agilent advises a 15 second reequilibration setting between gas modes. Even though we verified that 15 seconds works well in most cases, I use 30 seconds just because, as my team is aware, based on experience, I am anal retentive about gas.
So reequilibration between modes is rapid.
We have an HPLC. All it takes to switch between HPLC and flow injection from our FAST autosampler (assuming the same standard introduction system) is to move the HPLC closer to the instrument, attach the HPLC tube to the nebulizer instead of peristaltic pump tubing. The same could be accomplished using the iCAP TQ as Michael Sperling said a couple of hours ago.
We have used the triple quad for transient signals in a cell gas mass shift mode, though it was not with the HPLC:
Fresquez MR, Gonzalez-Jimenez N, Gray N, Valentin-Blasini L, Watson CH, Pappas RS. Electrothermal vaporization-QQQ-ICP-MS for determination of chromium in mainstream cigarette smoke particulate. J. Anal. Toxicol. 2017;41: doi: 10.1093/jat/bkx010.
HPLC should be even easier in single quad mode.
R. Steven Pappas, Ph.D.
Team Lead, Tobacco Inorganics Group
Centers for Disease Control & Prevention
4770 Buford Highway, NE
M.S. F44, Building 110
Atlanta, GA 30341-3717, USA
From: PLASMACHEM-L: Analytical Chem.(ICP's, DCP's, MIP's). [mailto:[log in to unmask]] On Behalf Of Johan Schijf
Sent: Thursday, March 09, 2017 9:50 AM
To: [log in to unmask]
Subject: Re: Agilent Triple Quad ICPMS? - 8800 or new 8900
Here is a related question:
We are thinking about purchasing an Agilent 8900 as an UPLC-QQQ system for trace level organometallic compounds and sulfur speciation. It would replace our Agilent 7500cx. We want to maintain our current more routine capabilities but we do not have the infrastructure to run both. Therefore my question is:
How well does the 8900 perform as a "regular" single-Q ICP-MS and how hard would it be to switch back and forth between that mode and hyphenated UPLC-QQQ?
"If I have seen further, it is by standing on the shoulders of Giants"
"Somewhere I think I have read an alternative quotation "I have stood on the shoulders of pygmies". It is a clever remark [...] There is, however the sobering thought that in a land of giants and pygmies there is no point in standing on the shoulders of a pygmy if one is a pygmy oneself"
"If I have seen further, it is because I was looking in the right direction"
Dr. Johan Schijf
Associate Professor, Aquatic Environmental Geochemistry UMCES/Chesapeake Biological Laboratory P.O. Box 38, 146 Williams Street Solomons, MD 20688-0038 Tel. (410) 326-7387 (office) 7392 (lab) Fax (410) 326-7341
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